Post-stroke recovery best with physio soon after

The human brain’s capacity to recover and rewire itself following a stroke peaks after around two weeks and diminishes over time, according to an international study conducted in London and Adelaide.

With results published in Neurorehabilitation and Neural Repair, the study followed the recovery of 60 stroke patients up to one year after their stroke.

Lead author Dr Brenton Hordacre from the University of South Australia said the multisite study showed conclusive evidence that the brain only has a small window of opportunity to more easily repair itself after stroke.

“Earlier animal studies suggested this was the case, but this is the first time we have conclusively demonstrated this phenomenon exists in humans,” Dr Hordacre said.

The researchers scanned the brains of stroke survivors as they recovered over 12 months. They found that in the initial days following an ischemic stroke (caused by a blocked artery to the brain), the brain has a greater capacity to modify its neural connections and its plasticity is increased.

“It is during this early period after stroke that any physiotherapy is going to be most effective because the brain is more responsive to treatment,” Dr Hordacre said.

The researchers used continuous transcranial magnetic stimulation (cTBS) to repetitively activate different hemispheres of the motor cortex to measure brain plasticity.

The Adelaide laboratory tested the stroke-damaged motor cortex, which is the main area that controls movement. The London laboratory tested the non-stroke-damaged hemisphere, which is also important to help recovery.

“Our assessments showed that plasticity was strongest around two weeks after stroke in the non-damaged motor cortex. Contrary to what we expected, there was no change in the damaged hemisphere in response to cTBS,” Dr Hordacre said.

Dr Hordacre said the findings confirm the importance of initiating therapy as soon as possible after a stroke. Current evidence indicates that less than eight minutes of daily therapy is dedicated to upper limb recovery within the first four weeks of a stroke.

“Delivering more treatment within this brief window is needed to help people recover after stroke. The next step is to identify techniques which prolong or even reopen a period of increased brain plasticity, so we can maximise recovery,” Dr Hordacre said.

Image credit: ©stock.adobe.com/au/Photographee.eu